姓 名：杨新旺
出生年月：1985.01
硕导/博导：博士研究生导师
学 位：博士研究生
所属科室：基础医学院
职 务：院长
邮 箱：yangxinwanghp@163.com; yangxinwang@kmmu.edu.cn
所获奖项：无
招生专业：人体解剖与组织胚胎学
研究领域：皮肤、黏膜损伤修复再生医学与活性肽
社会兼职：中国解剖学会临床神经解剖学会副主任委员、中国毒理学会生物毒素毒理专业委员会委员、云南省细胞生物学学会副理事长、生物化学与分子生物学学会常务理事等、Exploration青年编委、Burns & Trauma青年编委、Zoological Research编委、《中华烧伤与创面修复杂志》通讯编委。
其他介绍：教授，博导，博士后合作导师，入选云南省医学高端人才、云南省高层次人才培养支持计划、昆明市中青年学术技术带头人、beat365中文官方网站“乘风人才”；“重大器官损伤修复再生与云南省特色天然产物”云南省博导团队、beat365中文官方网站“皮肤黏膜损伤修复再生医学”一流学科团队、beat365中文官方网站“肽类分子探针与候选药物创新团队”带头人；指导研究生获得云南省优秀博士毕业论文3篇、优秀硕士毕业论文6篇。以通讯/第一作者身份发表于SCI研究论文80余篇，H指数33，获得国家发明专利授权近50项，其中21项实现技术转移。
主持或参加科研项目及人才计划项目情况（按时间倒序排序）：
1. 云南省医学高端人才，2026/01-2030/12,50万元，在研，主持。
2.云南省教育厅皮肤黏膜损伤修复再生与活性肽重点实验室，2025/11-2028/10，60万元，在研,主持。
3. 国家自然科学基金地区基金项目，32360138，蝌蚪来源的促皮肤创面组织再生肽类分子群的识别、功能及机制研究, 2024/01-2027/12, 33万元，在研，主持。
4. 云南省基础研究重点项目，202301AS070036，云南产臭蛙来源的促皮肤创面组织再生活性肽资源库的建立, 2023/06-2026/05, 50万元，在研，主持。
5. 云南省基础研究杰出青年项目，202301AY070001-301，短肽促皮肤创面组织再生的活性及作用机制研究, 2023/06-2026/05, 40万元，在研，主持。
6. beat365中文官方网站中青年学科带头人及后备人选——“乘风”人才, 2023/07-2026/07，50万元，在研，主持。
7.beat365中文官方网站“皮肤黏膜损伤修复再生医学”一流学科团队，2024/07-2029/06，250万元，在研，主持。
8.云南特色植物提取实验室开放研究项目重点项目，YKKF2024003，抗光老化肽的筛选、识别与机制研究，2025/01-2026/12，50万元，在研，主持。
9.企业横向课题，2024/11-2029/11，250万元，在研，主持。
代表性成果：
期刊论文：
1. Xiao H#, Li S#, Qi R#, Hu Y, Jiang X, Luo J, Wu J, Zhang L, Xu S, Lu D*, Yang X*. Chen Q*, Liu S*. Molecular mechanism of phosphate import by the bacterial PstSCAB transporter. Nature Communications. 2026 Feb 3;17(1):2294.
2. Xin Liu#, Jie Liu#, Bin Li#, Zihan Qian, Guorui Zhang, Haoyang Gan, Zhiruo Li, Xiaoya Han, Zhuo Wang, Yuansheng Li, Xinyan Zheng, Litian Wang, Saige Yin, Wenrou Su, Li He*, Ying Wang*, Mingying Luo*, Xinwang Yang*, First identification of an amphibian-derived peptide with anti-vascular aging activity. Zoological Research. DOI: 10.24272/j.issn.2095-8137.2025.499.
3. Zhe Fu#, Jingyu Jiang#, Qiuye Jia#, Hao Zhu, Xinhe Shen, Yunjian Luo, Shaowei Chen, Tuanqing Li, Yutong Wu, Naixin Liu*, Kun Guo*, Ying Wang*, Xinwang Yang*. The self-assembling amphibian-derived peptide (RADA)4-FZ1 pioneers a novel therapeutic platform for diabetic skin wound management. Chemical Engineering Journal. Volume 530, 15 February 2026, 173231.
4. Guo-Ji Yan#, Xu-Yang Wang#, Xin-Ying Shi#, Min-Nan Lu, Dan Wang, Chen-Jun Ye, Shan-Shan Li, Chen-Di Yang, Xi-Wen Liang, Yi-Jian Zhang, Xinwang Yang*, Tao Hu*, Yan-bin Xiyang*. miR-449a is involved in Alzheimer's disease pathology through targeted regulation of Navβ2. Zoological Research. DOI: 10.24272/j.issn.2095-8137.2025.430.
5. Wang L#, Fu Z#, Su Y#, Yin W, Wang X, Zhao W, Wang J, Li Y, Liu N, Su W, He L*, Yin S*, Wang Y*, Yang X*. Cyclic Heptapeptide FZ1 Acts as an Integrin αvβ3 Agonist to Facilitate Diabetic Skin Wound Healing by Enhancing Angiogenesis. Journal of Medicinal Chemistry. 2025 Sep 25;68(18):19503-19520.
6. Ru ZQ#, Wu YT#, Yang CY#, Yang YT, Li YJ, Liu M, Peng Y, Yang YL, Wang JY, Jia QY, Li YS, Fu Z, Yang MF, Tang J, Fan Y, Liu CX, Su WR, Liu NX*, He L*, Wang Y*, Yang XW*. Ultra-short cyclic peptide Cy RL-QN15 acts as a TLR4 antagonist to expedite oral ulcer healing. Zoological Research. 2025 Sep 18;46(5):1187-1202.
7. Ye CJ#, Liu LN#, Lu MN#, Hu T#, Zhou Y, Wang D, Zhao HR, Yan GJ, Shi XY, Song JF, Li SS, Yin SG, Zong ST, Yang XW*, Xiyang YB*. Peptide OM-LV20 demonstrates neuroprotective effects by attenuating mitochondria-mediated neuronal apoptosis and dysfunction in mice with traumatic brain injury. Zoological Research. 2025 Nov 18;46(6):1447-1464.
8. Yuansheng Li#, Qiuye Jia#, Naixin Liu, Saige Yin, Junyuan Wang, Yujing Ding, Yuliu Yang, Ying Peng, Zeqiong Ru, Shaoyang Zhang, Jun Sun, Ying Wang *, Li He*, Kun Guo*, Xinwang Yang*. Peptide RL-QN15 regulates functions of epidermal stem cell to accelerate skin wound regeneration via the FZD8/β-catenin axis. Exploration 20240090. https://doi.org/10.1002/EXP.20240090.
9. Dan Ni#, Naixin Liu#, Ying Peng#, Yun Li, Shaoyang Zhang, Zeqiong Ru, Yuliu Yang, Junyuan Wang, Xiaohan Sun, Yujing Ding, Chengxin Liu, Ying Wang*, Buliang Meng *, Xinwang Yang *. MiR-181d-5p affects skin wound healing processes via the Ikbkg/NF-κB axis. International Journal of Biological Macromolecules, 2025 Sep;322(Pt 4):147007.
10. Ziqi Wei#, Xingguo Li#, Jinyi Zhou, Yuxuan Zhou, Zhaoxun Xiao, Qian Yang, Xin Liu, Zeqiong Ru, Ying Peng, Yuliu Yang1, Yujing Ding, Ying Wang*, Meifeng Yang*, Xinwang Yang*. Inhibition of miRNA-365-2-5p targeting SIRT1 can regulate keratinocytes and promote wound healing. The FASEB Journal, 2025 Apr 30;39(8): e70560.
11. Li Y, Fu Z, Deng C, Qian J, Wang Z, Lu Y, Zhang S, Liu G, Wen J, Chen Y, Jiang J, Liu X, Zheng X, Shen X, Su W, Yang M, Tang J, Wang Y, Meng B, Yang X. miR-301a-5p regulated IKKβ/NF-κB axis and macrophage polarization to accelerate skin wound healing. International Journal of Biological Macromolecules. 2025 Jun;311(Pt 4):143995.
12. Jia Q#, Fu Z#, Li Y#, Kang Z, Wu Y, Ru Z, Peng Y, Huang Y, Luo Y, Li W, Hu Y, Sun X, Wang J, Deng Z*, Wu C*, Wang Y*, Yang X*. Hydrogel Loaded with Peptide-Containing Nanocomplexes: Symphonic Cooperation of Photothermal Antimicrobial Nanoparticles and Prohealing Peptides for the Treatment of Infected Wounds. ACS Applied Materials & Interfaces. 2024 Mar 20;16(11):13422-13438.
13. Li C#, Xiong Y#, Fu Z#, Ji Y, Yan J, Kong Y, Peng Y, Ru Z, Huang Y, Li Y, Yang Y, He L*, Tang J*, Wang Y*, Yang X*.The direct binding of bioactive peptide Andersonin-W1 to TLR4 expedites the healing of diabetic skin wounds. Cellular & Molecular Biology Letters. 2024 Feb 5;29(1):24.
14. Wu YT#, Ru ZQ#, Peng Y#, Fu Z, Jia QY, Kang ZJ, Li YS, Huang YB, Yin SG, Guo K, Liu NX, Feng CA, Tang J, Zhang BY*, Yang Z*, Wang Y*, Yang XW*. Zoological Research. 2024 Nov 18;45(6):1287-1299.
15. Sun D#, Guo K#, Liu N, Li Y, Li Y, Hu Y, Li S, Fu Z, Wang Y, Wu Y, Zhang Y, Li J, Li C, Wang Z, Kang Z, Sun J*, Wang Y*, Yang X*. Peptide RL-QN15 promotes wound healing of diabetic foot ulcers through p38 mitogen-activated protein kinase and smad3/miR-4482-3p/vascular endothelial growth factor B axis. Burns & Trauma. 2023 Nov 15;11:tkad035.
16. Li Y#, Jin T#, Liu N#, Wang J#, Qin Z, Yin S, Zhang Y, Fu Z, Wu Y, Wang Y, Liu Y, Yang M, Pang A*, Sun J*, Wang Y*, Yang X*. A short peptide exerts neuroprotective effects on cerebral ischemia-reperfusion injury by reducing inflammation via the miR-6328/IKKβ/NF-κB axis. Journal of Neuroinflammation. 2023 Feb 28;20(1):53.
17. Li C#, Fu Z#, Jin T#, Liu Y, Liu N, Yin S, Wang Z, Huang Y, Wang Y, Zhang Y, Li J, Wu Y, He L*, Tang *J, Wang Y*, Yang X*. A frog peptide provides new strategies for the intervention against skin wound healing. Cellular & Molecular Biology Letters 2023 Jul 28;28(1):61.
18. Wu Y#, Wang Y#, Fu Z, Sun H, Liu Y, Li C, Wang Y, Liu N, Huang Y, Yin S, Guo K, Feng C, Tang J, He L, Yang Y*, Yang X*. Peptide RL-QN15 promotes regeneration of epidermal nerve fibers and recovery of sensory function in diabetic skin wounds. The FASEB Jouranl. 2023 Apr;37(4):e22892.
19. Yin S#, Pang A#, Liu C#, Li Y, Liu N, Li S, Li C, Sun H, Fu Z, Wang Y, Zhang Y, Yang M*, Sun J*, Wang Y*, Yang X*. Peptide OM-LV20 exerts protective effects on astrocytes via the ‘PAC1R/JNK/TPH1’ axis to resist oxidative stress. Journal of Biological Chemistry. 2022 Aug 26; 298(10): 102429.
20. Zhang Y#, Wang Y#, Zeng L, Liu Y, Sun H, Li S, Wang S, Shu L, Liu N, Yin S, Wang J, Ni D, Wu Y, Yang Y*, He L*, Meng B*, Yang X*. Amphibian-derived peptide homodimer OA-GL17d promotes skin wound regeneration through the miR-663a/TGF-β1/Smad axis. Burns & Trauma. 2022 Jul 12;10:tkac032.
21. Fu Z#, Sun H#, Wu Y#, Li C#, Wang Y, Liu Y, Li Y, Nie J, Sun D, Zhang Y, Liu N, Guo K, Yin S, Jia Q, Yang Y*, He L*, Wang Y*, Yang X*. A cyclic heptapeptide-based hydrogel boosts the healing of chronic skin wounds in diabetic mice and patients. NPG Asia Materials. (2022) 14:99.
22. Sun H#, Yang Y#, Wu Y#, Fu Z#, Zhang Y, Liu Y, Nie J, Wang Y, Wang H, Mai B, Fu N, Li C, Liu N, Li Y, Deng Z*, He Li*, Wang Y*, Yang X*. Zinc alginate hydrogels with embedded RL-QN15 peptide-loaded hollow polydopamine nanoparticles for diabetic wound healing therapy. Materials & Design, 222 (2022) 111085.
23. Qin P#, Tang J#, Sun D#, Yang Y#, Liu N, Li Y, Fu Z, Wang Y, Li C, Li X, Zhang Y, Liu Y, Wang S, Sun J, Deng Z*, He L*, Wang Y*, Yang X*, Zn2+ Cross-linked Alginate Carrying Hollow Silica Nanoparticles Loaded with RL-QN15 Peptide Provide Promising Treatment for Chronic Skin Wounds. ACS Applied Materials & Interfaces. 2022 Jul 6;14(26):29491-29505.
24. Shu L#, Yang M#, Liu N#, Liu Y, Sun H, Wang S, Zhang Y, Li Y, Yang X*, Wang Y*. Short Hexapeptide Optimized from Rice-Derived Peptide 1 Shows Promising Anti-hyperuricemia Activities. Journal of Agricultural and Food Chemistry. 2022 Jun 8;70(22):6679-6687.
25.Sun H#, Wang Y#, He T#, He D#, Hu Y, Fu Z, Wang Y, Sun D, Wang J, Liu Y, Shu L, He L*, Deng Z*, Yang X*. Hollow polydopamine nanoparticles loading with peptide RL-QN15: a new pro-regenerative therapeutic agent for skin wounds. Journal of Nanobiotechnology. 2021 Oct 9；19 (1), 304.
26. Qin P#, Meng Y#, Yang Y#, Gou X, Liu N, Yin S, Hu Y, Sun H, Fu Z, Wang Y, Li X, Tang J, Wang Y*, Deng Z*, Yang X*. Mesoporous polydopamine nanoparticles carrying peptide RL-QN15 show potential for skin wound therapy. Journal of Nanobiotechnology. 2021 Oct 9;19(1):309.
27. Wang Y#, Feng Z#, Yang M#, Zeng L#, Qi B, Yin S, Li B, Li Y, Fu Z, Shu L, Fu C, Qin P, Meng Y, Li X, Yang Y, Tang J*, Yang X*. Discovery of a novel short peptide with efficacy in accelerating the healing of skin wounds. Pharmacological Research. 2021 Jan; 163:105296.
